Tag: Fiona Bruce

The below Parliamentary question was asked by Fiona Bruce on 2014-04-29.

To ask the Secretary of State for Education, pursuant to the Written Statement of 9 April 2014, Official Report, column 1417WS, on qualifications reform, and the Answer of 7 April 2014, Official Report, column 42W, on in vitro fertilisation, whether the study of the human genome as part of the revised content for GCSEs in science will involve pupils learning that genomic DNA is only found in the cell nucleus and that mitochondrial DNA is not part of the genome.

Elizabeth Truss

The requirement that students study the genome and gene expression in the revised GCSE combined science and GCSE biology criteria covers all organisms, and is not specific to the human genome. It is therefore given at a level of generality that applies to all living things. The only specific reference in this section of the criteria to the human genome is in the context of the statement that requires students to be able to discuss the potential importance for medicine of our increasing understanding of the human genome.

In developing their specifications which meet these criteria, Awarding Organisations may choose to include microorganisms, humans or any other organism when they cover the genome and gene expression.

The below Parliamentary question was asked by Fiona Bruce on 2014-04-29.

To ask the Secretary of State for Health, what assessment his Department has made of the meta-analysis by Huang Y et al. published in the journal Cancer Causes Control in November 2013, investigating the link between termination of pregnancy and breast cancer.

Jane Ellison

The Royal College of Gynaecologists and Obstetricians (RCOG) reviewed its evidence based guidance on abortion (The Care of Women Requesting Induced Abortion) in 2011 in which the issue of a link between abortion and breast cancer was given careful consideration.

When the RCOG carries out the next review of its guidance, consideration will be given to all relevant research and evidence available that has come to light, to help inform the guidance and recommendations.

The below Parliamentary question was asked by Fiona Bruce on 2014-04-29.

To ask the Secretary of State for Health, pursuant to the Answer of 7 April 2014, Official Report, column 42W, on In vitro fertilisation, (a) what the evidential basis is for his statement that no genomic DNA is found in the mitochondria but only in the cell nucleus, (b) what account he took of the data on the human genome available in the ENSEMBL and OMIM databases in preparing that statement and (c) what genetic modifications applied to the eggs or embryos would prevent any nuclear DNA from the eggs or embryo donor being inherited by the resulting child.

Jane Ellison

We have been advised by the Wellcome Trust that whole mitochondrial DNA genome sequencing has revealed no evidence of nuclear genomic DNA inside mitochondria and data on the human genome available in the ENSEMBL and OMIM databases confirms that there is no nuclear genomic DNA in the mitochondria.

Inheritance of nuclear DNA from the donor egg is prevented in the Maternal Spindle Transfer technique through the removal of the spindle from the donor egg. Given that the nuclear DNA in the form of condensed chromosomes is attached to the spindle, nuclear genomic DNA from the donor will be removed and not inherited by the resulting child. Techniques that allow the visualisation of condensed chromosomes in eggs are used to ensure that all the chromosomes are removed.

For embryos used in the Pronuclear Transfer technique, the nuclear genomic DNA is enclosed within the nuclear membrane of the maternal (egg-derived) and paternal (sperm-derived) pronuclei. The donor nuclear genomic DNA will be removed when the pronuclei are removed.

There is no universally agreed definition of genetic modification in humans. The Government has adopted a working definition for the purpose of taking forward the draft mitochondrial donation regulations, that genetic modification involves the germ-line modification of nuclear DNA that can be passed on to future generations. Therefore, the Government does not accept that mitochondrial donation amounts to genetic modification.

The below Parliamentary question was asked by Fiona Bruce on 2014-04-29.

To ask the Secretary of State for Health, what guidance he gives on ensuring that all women seeking an abortion are given accurate, complete, balanced and up-to-date information regarding the potential health risks of the procedure.

Jane Ellison

Clinical guidance from the Royal College of Obstetricians and Gynaecologists, The Care of Women Requesting Induced Abortion (November 2011) recommends that services should make sure that “written, objective, evidence-guided information is available for women considering abortion to take away before the procedure. Information should be in a variety of languages and formats”. In addition, “staff providing abortion services should provide up-to-date evidence-guided information, supported by local data where robust, about complications and sequelae of abortion”.

The Department requires independent sector providers to provide women with impartial evidence-based information (verbal and written) which includes “what to expect, during and after the abortion (to include potential side effects, complications and any clinical implications)”. Also the Care Quality Commission’s Essential Standards of Quality and Safety require that “the risks, benefits and alternative options are discussed and explained in a way that the person who uses the service is able to understand.”